Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells

应用领域:蛋白/抗体/蛋白质组

检测样品:Primary human islets

检测项目:质谱

参考标准:-

方案摘要

The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.

In this work we leveraged the analytical performance of the  timsTOF Pro to identify expression of low-level enzymes for  the first time in primary insulin-secreting beta cells (β-cells). We  found that these proteins are critical, functional components of  key metabolic pathways which  can support β-cell survival under  inflammatory stress, an emerging disease etiology of diabetes.Confirmation that these factors  are present and functional specifically in pancreatic β-cells points  to new therapeutic avenues for  human diabetes.

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