应用领域:蛋白/抗体/蛋白质组
检测样品:Primary human islets
检测项目:质谱
参考标准:-
The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.
In this work we leveraged the analytical performance of the timsTOF Pro to identify expression of low-level enzymes for the first time in primary insulin-secreting beta cells (β-cells). We found that these proteins are critical, functional components of key metabolic pathways which can support β-cell survival under inflammatory stress, an emerging disease etiology of diabetes.Confirmation that these factors are present and functional specifically in pancreatic β-cells points to new therapeutic avenues for human diabetes.