ACADM antibody
Cat.#: 2758-1
Rabbit Monoclonal Antibody
Clone ID: EPR3707
Swiss Prot: P11310
Mol Weight: 43kDa
Size: 100ul
Description
Medium-chain acyl-CoA dehydrogenase (MCAD, ACADM) is a highly regulated member of a family of mitochondrial flavoenzymes that is essential for the beta-oxidation of medium chain fatty acids (1, 2). ACADM is active with acyl chain length of C4-C16. It is one of three similar enzymes that catalyze the initial step of fatty acid beta-oxidation (3). Deficiency of ACADM is a common inherited defect in energy metabolism (1).
Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 5,000
IHC: 1:250 - 500
ICC: 1:50 - 100
IP: 1:10
Species Reactivity
Human, Mouse, Rat
Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only
Products Data
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Western blot analysis on (A) fetal heart, (B) fetal liver, (C) HeLa and (D) HepG2 cell lysates using anti-ACADM RabMAb (cat. #2758-1).
Immunohistochemical analysis of paraffin-embedded human kidneytissue using anti-ACADM RabMAb (cat. #2758-1).
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ACADM RabMAb (cat. #2758-1).
Specificity
A synthetic peptide corresponding to residues in human ACADM was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ACADM antibody, ACAD1 antibody, FLJ18227 antibody, FLJ93013 antibody, FLJ99884 antibody, MCAD antibody, MCADH antibody, Medium-chain specific acyl-CoA dehydrogenase, mitochondrial antibody, antibody
Description References
1. Zhang Z.F., et al. Biochemistry 31:81-89, 1992. 2. Kevin P. Battaile, et al. Elsevier Science B.V., 1998. 3. Kelly D.P., et al. Proc. Natl. Acad. Sci. U.S.A. 84:4068- 4072, 1987.
