ACVRL1 antibody
Cat.#: 2940-1
Rabbit Monoclonal Antibody
Clone ID: EPR4074
Swiss Prot: P37023
Mol Weight: 56kDa
Size: 100ul
Description
ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1,000-10,000
Species Reactivity
Human, Mouse, Rat
Products Data
Western blot analysis on (A) JAR, (B) Daudi, and (C) Jurkat cell lysates using anti-ACVRL1 RabMAb (cat. # 2940-1).
Specificity
A synthetic peptide corresponding to residues in human ACVRL1 was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ACVRL1 antibody, ACVRLK1 antibody, ALK-1 antibody, ALK1 antibody, HHT antibody, HHT2 antibody, ORW2 antibody, SKR3 antibody, TSR-I antibody, Serine/threonine-protein kinase receptor R3 antibody, TGF-B superfamily receptor type I antibody
Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.
