Activin A Receptor Type IB antibody
Cat.#: S1042
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P36896
Mol Weight: 56.81kDa
Size: 100ug
Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq]
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
Species Reactivity
Human
Other species have not been tested
Products Data
Sample(30ug whole cell lysate)
A:293T
7.5% SDS PAGE
diluted at 1:500
Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 131 and 435 of Human ACVR1B
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
ACVR1B antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, SKR2 antibody, Activin receptor type-1B antibody, Serine/threonine-protein kinase receptor R2 antibody
