ALS2CR2 Antibody(C-term)
Cat.#: T2031
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q9C0K7
Mol Weight: 47kDa
Size: 100ug
Description
ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.
Recommended Applications
WB, ELISA
Applications and Recommended Dilution Factors
WB: 1:100~500
ELISA: 1:1,000
Species Reactivity
Human
Products Data
Western blot analysis of ALS2CR2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). ALS2CR2 (arrow) was detected using the purified Pab.
Specificity
This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389~418 amino acids from the C-terminal region of human ALS2CR2.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Names
STRADB antibody, ALS2CR2 antibody, CALS-21 antibody, ILPIP antibody, ILPIPA antibody, MGC102916 antibody, PAPK antibody, STE20-related kinase adapter protein beta antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibody, CALS-21 antibody, ILP-interacting protein antibody, Pseudokinase ALS2CR2 antibody
Description References
Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003).
Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002).
Hadano, S., et al., Genomics 71(2):200-213 (2001).
