| Catalogue Number | ANT-211 | ||||
| Synonyms | MYC, CMYC, C-MYS, V-MYC, P64. | ||||
| Type | Mouse Anti Human Monoclonal. | ||||
| Introduction | c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. | ||||
| Clone | NYRhc-myc. | ||||
| Immunogen | synthetic peptides. | ||||
| Ig Subclass | mouse IgG1. | ||||
| Purification Method | Protein A. | ||||
| Protein concentration | 1mg/ml in PBS (after reconstitution). | ||||
| Storage Procedures | Antibody is shipped lyophilized at ambient temperature. | ||||
| Reconstitution | Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4oC. | ||||
| Titer | By Western blot 1:2,000 dilution will yield a strong band in WB. | ||||
| Additional Information | This antibody was produced in BALB/c mice UsageProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||
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