| Catalogue Number | ANT-136 | |||||
| Synonyms | Integrin, alpha M, CR3A, MO1A, CD11B, MAC-1, MAC1A, MGC117044, ITGAM TypeRat Anti Mouse Monoclonal. | |||||
| Introduction | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain. | |||||
| Clone | mCD11b. | |||||
| Immunogen | Purified mouse LN CD4+ T cells. | |||||
| Ig Subclass | Rat IgG2b. | |||||
| Purification Method | Ion exchange column. | |||||
| Protein concentration | 1mg/ml in PBS (after reconstitution). | |||||
| Storage Procedures | Lyophilized: store at 4oC. After reconstitution, if not intended for use within a month, aliquot and store at -20oC. | |||||
| Reconstitution | Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4oC. | |||||
| Antibody Properties | Staining and blocking antibody. For staining, use 10 µl/106 cells. This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator. | |||||
| Available Conjugates | This antibody is only available conjugated to FITC. | |||||
| Usage | Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |||||
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