ADAMTS4 Antibody(C-term)
Cat.#: T2386
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: O75173
Mol Weight: 90kDa
Size: 100ug
Description
ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Recommended Applications
WB, ELISA
Applications and Recommended Dilution Factors
WB: 1:50~100
ELISA: 1:1,000
Species Reactivity
Human, Mouse
Products Data
Western blot analysis of anti-ADAMTS4 Antibody (C-term) in mouse cerebellum tissue lysates (35ug/lane). ADAMTS4 (arrow) was detected using the purified Pab.
Specificity
This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713~743 amino acids from the C-terminal region of human ADAMTS4.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Names
ADAMTS4 antibody, ADAMTS-2 antibody, ADAMTS-4 antibody, ADMP-1 antibody, KIAA0688 antibody, A disintegrin and metalloproteinase with thrombospondin motifs 4 antibody, ADMP-1 antibody, Aggrecanase-1 antibody
Description References
Tortorella M.D., Burn T.C.Science 284:1664-1666(1999)
Tortorella M.D., Pratta M.A., Liu R.-Q.J. Biol. Chem. 275:25791-25797(2000)
