| Catalogue Number | ANT-223 | ||||
| Synonyms | MYC, CMYC, C-MYS, V-MYC, P64. | ||||
| Type | Mouse Antibody Monoclonal. | ||||
| Introduction | c-Myc is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of c-Myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. | ||||
| Clone | PMYCSHG. | ||||
| Description | Monoclonal antibodies are produced by immunizing mouse with synthetic peptide (EQKLISEEDL) coupled to KLH. | ||||
| Ig Subclass | Mouse IgG1. | ||||
| Formulation | 1×PBS & 50% glycerol. | ||||
| Stability / Shelf Life | 2 years at -20°C. 1 month at 4°C. | ||||
| Dilution | Western Blotting: 0.5µg/ml. | ||||
| Applications | Western Blot, Immunoprecipitation. | ||||
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||
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