5HT2C Receptor antibody
Cat.#: S2043
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P28335
Mol Weight: 51.83kDa
Size: 100ul
Description
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
Species Reactivity
Human
Other species have not been tested
Products Data
Sample (30ug of whole cell lysate)
A: A431
10% SDS PAGE
diluted at 1:1000
Specificity
Synthetic peptide contain a sequence corresponding to a region within amino acids 387 and 446 of human HTR2C
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
HTR2C antibody, 5-HT2C antibody, 5-HTR2C antibody, HTR1C antibody, 5-hydroxytryptamine receptor 2C antibody, Serotonin receptor 2C antibody
