产地：usa
货号：C3662
名称：环孢菌素 A Cyclosporin A
CAS号: 59865-13-3 别名: 抗生素 S 7481F1, 环孢霉素
分子量: 1202.61
Biochem/physiol Actions
具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶(蛋白磷酸酶 2B)的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。
相关类型 Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecules, CI-CY, Cell Biology, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators, Immunomodulators and Antibiotics, Inhibits an Enzyme, Mechanism of Action, Peptides for Cell Biology, Protein Phosphatase 2B (Calcineurin/PP2B), Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Inhibitors
Quality Level PREMIUM
biological source from Tolypocladium inflatum
assay ≥95% (HPLC)
form solid
color white
solubility dichloromethane: soluble10 mg/mL
ethanol: soluble10 mg/mL
DMSO: soluble50 mg/mL
chloroform: soluble6 mg/mL
H2O: insoluble
storage temp. 2-8°C
