氨基蝶呤
Aminopterin
别名: 4-氨基-PGA, 4-氨基叶酸, N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸
分子量: 440.41
CAS号: 54-62-6
Linkage
比甲氨喋呤更有效，但毒性也更强。
Biochem/physiol Actions
叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。
相关类型 A-AM, Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research,
Cell Biology, Cell Signaling Enzymes, D to K, DNA Synthesis Inhibitors, DNA metabolism, Dihydrofolate reductase, Enzyme Inhibitors by Enzyme, Folic Acid Metabolism, Inhibitors, Metabolic Pathways, Metabolomics
assay ~98% (TLC)
form powder
color yellow
solubility 2 M NaOH: soluble50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)
DMSO: soluble (Solutions may be stored for 1-2 days at 4°C.)
abs. ε1M/261 nm, 0.1 M NaOH 25,700
ε1M/282 nm, 0.1 M NaOH 24,500
ε1M/373 nm, 0.1 M NaOH 8,100
storage temp. −20°C
