BML-PW9365******mu;l
BML-PW9365-0025 25 μl
Parkin is a ubiquitin-protein ligase (E3), and mutations in the Parkin gene appear to be closely associated with autosomal recessive juvenile Parkinson’s disease. Parkin has been localised to Lewy bodies in patients with sporadic Parkinson’s disease, and in peri-nuclear aggresome-like inclusions in cells over-expressing wild-type Parkin where proteasomal activity has also been inhibited4. Both types of inclusion also contain ubiquitin, α-synuclein, proteasomal subunits and heat shock proteins.
A recent paper suggests that loss of proteasomal activity leads to Parkin accumulation with a concomitant reduction in E3 ligase activity resulting in Lewy body formation5.Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy (mitophagy).
Product Specification
Formulation: Liquid. In PBS.
Immunogen: Synthetic peptide corresponding to aa 399-415 (CE339QARWEAASKETIK412) of human parkin. A single amino acid substitution (A405E) exists in both the rat and mouse homologues.
Source/Host: From rabbit.
Specificity: Recognizes human parkin.
Application: Immunohistochemistry
Immunoprecipitation
Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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