BML-SA606******micro;l
BML-SA606-0050 50 µl The mammalian melastatin-related transient receptor potential (TRPM) is a subfamily of the TRP family. The TRPM proteins share structural homology with other members of the TRP superfamily channels; six putative transmembrane domains, and cytoplasmic N-terminus and C-terminus. However, due to their long N-terminus and C-terminus they were also named the long TRP channel family. TRPM7 and TRPM6 are involved in Mg2+ homeostasis and are unique among the TRP family members, possessing a functional kinase domain at their C-terminus.
Although the kinase is not necessary to the function of the channel it may have a role in modulating the activation of the channel. Research has demonstrated that TRPM7 is a critical mediator of anoxic cell death.
Product Specification
Alternative Name: Transient receptor potential cation channel subfamily M member 7, TRP-PLIK, Channel kinase 1, LTRPC7
Formulation: Lyophilized from PBS, pH 7.4, 1% BSA and 0.05% sodium azide.
Immunogen: Synthetic peptide corresponding to aa 1146-1165 of human TRPM7 (TRP-PLIK, channel-kinase 1).
Source/Host: From rabbit.
Specificity: Recognizes mouse and rat TRPM7.
Application: Immunocytochemistry
Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
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