Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.
Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.
Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
25g, 100g
Chemical structure: tetracycline
Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Store under inert gas. Keep in a dry place.
| Related Categories | Antibacterial, Antibiotics A to Z, Antibiotics T-Z,Antibiotics by Application, Chemical Structure Class, |
| biological source | synthetic |
| InChI Key | OFVLGDICTFRJMM-WESIUVDSSA-N |
| assay | ≥98.0% (NT) |
| form | powder |
| optical activity | [α]20/D −230±5°, c = 1% in methanol |
| impurities | 4-11% water |
| (Residue on ignition) | ≤0.5% |
| color | yellow to yellow-orange |
| mp | 172-174 °C (dec.) |
| solubility | 95% ethanol: soluble 12.5 mg/mL |
| Mode of action | protein synthesis | interferes |
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| storage temp. | 2-8°C |
| Gene Information | human ... CYP1A2(1544), TERT(7015) |
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