别名: : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
经验分子式（希尔表示法） C17H17N3 · HCl
分子量 299.80
PubChem Substance ID 329818415
5, 25 mg in glass bottle
The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
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| Related Categories | Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, N, Potassium Channel Modulators, |
| InChI Key | VWEKCDTXUUPBNA-PFEQFJNWSA-N |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | DMSO: >10 mg/mL |
| H2O: insoluble | |
| storage temp. | 2-8°C |
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