| 应用 |
A methoxy-substituted catechol commonly used as an inhibitor of NADPH oxidase.
4'-Hydroxy-3'-methoxyacetophenone is used as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which is an enzyme responsible for reactive oxygen species production. It is also useful in the treatment of various inflammatory diseases and atherosclerosis. Further, it shows an anti-inflammatory activity and improves endothelial function by reducing oxidative stress. In addition to this, it is used for studying nitric oxide regulated processes in plants. |
| 产品介绍 |
Apocynin is a methoxy-substituted catechol that is commonly used as an inhibitor of Mox and Nox (NADPH oxidase) (IC50=10 μM). Because of Abocynin's inhibition of NADPH oxidase, ROS production is also inhibited. Studies show the compound's ability to decrease superoxide generation in bovine pulmonary arteries as well as neutrophils and macrophages (10 mM). In experimental rats, apocynin has displayed anti-inflammatory activity and can improve endothelial function by reducing oxidative stress and improved NO bioavailability. Reportedly prevents phagocytosis of MBP (myelin) by macrophages. Also has proven to be a useful product for studying NO-regulated processes in plants. |
| 别名 |
乙酰香草酮;香草乙酮;夹竹桃麻素;4'-羟基-3'-甲氧基乙酰苯;4'-羟基-3-甲氧基苯乙酮;Acetovanillone;Apocynin |
