| 产品介绍 |
IOX2是低氧诱导因子（HIF）脯氨酰羟化酶（PHD）抑制剂，在细胞中对PHD2/ELGN-1的IC50为21 nM，对FIH无活性。 |
| 备注 |
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| 生化机理 |
IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. |
| 别名 |
IOX 2;IOX-2;JICL38;N-((4-羟基-2-氧代-1-(苯基甲基)-1,2-二氢-3-喹啉基)羰基)甘氨酸;;IOX 2;IOX-2;JICL38; N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine; N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine |
