FG-4592
面议
血管生成

FG-4592

  • 全国
  • 阿拉丁
  • 上海
  • 生产商
  • 现货
  • 3
  • 1
上海阿拉丁生化科技股份有限公司
高级会员 高级会员
产品特点
规格信息
货号 CAS号
F126178-250mg 808118-40-3
F126178-50mg 808118-40-3
F126178-10mg 808118-40-3
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产品描述
  • 分子式 C19H16N2O5
  • 分子量352.34
  • Beilstein号
  • EC号
  • MDL号
  • PubChem编号

属性

溶解性 DMSO >70 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件 储存温度2-8°C

描述

产品介绍 FG-4592是一种HIF α脯氨酰羟化酶抑制剂,并能稳定HIF-2,同时诱导EPO产生。
备注 FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. Phase 2/3.
生化机理

FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. A phase II clinical trial of FG-4592 has been competed in the treatment of chronic kidney disease.

别名 N-[(4-羟基-1-甲基-7-苯氧基-3-异喹啉基)羰基]甘氨酸;FG4592;FG 4592;N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine;[[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid
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