货号 | CAS号 |
---|---|
N129969-10mg | 890090-75-2 |
N129969-50mg | 890090-75-2 |
N129969-5mg | 890090-75-2 |
N126055-10mg | 548472-68-0 |
N126055-50mg | 548472-68-0 |
溶解性 | DMSO 100 mg/mL Water <1 mg/mL Ethanol 30 mg/mL |
存贮条件 | 储存温度-20°C |
产品介绍 | Nutlin-3是一种有效的,选择性的Mdm2(依赖环指状的泛素蛋白连接酶和p53)拮抗剂,IC50为90 nM。可稳定p53缺陷的细胞中的p73。 |
备注 | Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM; stabilizes p73 in p53-deficient cells. |
别名 | 4-[[4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮;4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone |