| 货号 | CAS号 |
|---|---|
| C126929-10mg | 693228-63-6 |
| C126929-1mg | 693228-63-6 |
| C126929-50mg | 693228-63-6 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 备注 | CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK |
| 生化机理 |
CYC-116 is an orally bioavailable，small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC-116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. |
| 别名 | 4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine;4-(2-amino-4-methylthiazol-5-yl)-N-(4-morpholinophenyl)pyrimidin-2-amine |
