| 应用 |
A synthetic Geldanamycin derivative and inhibitor of Hsp90. |
| 产品介绍 |
Alvespimycin (17-DMAG; KOS-1022; NSC 707545)是水溶性HSP90抑制剂，IC50为62 nM。 |
| 生化机理 |
17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG .17-DMAG is described to bind and inhibit the activity of Hsp90 (heat shock protein 90), a cellular chaperone that is over expressed in many cancers, and which participates in folding of proteins found in multiple signal transduction pathways. |
| 别名 |
17-DMAG; KOS-1022; NSC 707545;阿螺旋霉素; 17-[2-(二甲基氨基)乙基氨基]-17-去甲氧基格尔德霉素;17-DMAG; KOS-1022; NSC 707545;17-Dimethylaminoethylamino-17-demethoxygeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin |
