Elesclomol (STA-4783)

属性

溶解性	DMSO ≥78mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	Elesclomol (STA-4783)是新型氧化应激诱导剂，能促肿瘤细胞凋亡。
备注	Elesclomol (STA-4783) is a novel potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.
生化机理	Elesclomol significantly induces the expression of heat shock stress response genes and metallothionein genes, a signature transcription profile indicative of oxidative stress in Hs294T cells。Elesclomol significantly inhibits the cell viability of SK-MEL-5, MCF-7, and HL-60 with IC50 of 110 nM, 24 nM and 9 nM, respectively.Elesclomol induces copper-dependent ROS generation and cytoxicity in yeast.
别名	STA-4783；伊利司莫; 丙二酸-1,3-二(2-甲基-2-(苯基硫酮甲基)酰肼);;STA-4783;STA4783;STA 4783； 1,3-bis(2-methyl-2-(phenylthioxomethyl)hydrazide)propanedioic acid