PF-04929113 (SNX-5422)

属性

溶解性	DMSO 104 mg/mL Water <1 mg/mL Ethanol 5 mg/mL
存贮条件	储存温度-20°C

描述

备注	PF******SNX-5422) is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. Phase 1/2.
生化机理	PF******s a potent and selective Hsp90 inhibitor with an IC50 of median 50 nM.
别名	(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;(1r,4r)-4-(2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate