| 应用 |
A potent and selective monopolar spindle 1 (Mps1) kinase inhibitor |
| 产品介绍 |
AZ3146是单极纺锤体1（Mps1）激酶抑制剂，IC50为35 nM，对FAK，JNK1，JNK2和Kit的抑制性较弱。 |
| 备注 |
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. |
| 生化机理 |
AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment. |
| 别名 |
9-环戊基-7,9-二氢-2-((2-甲氧基-4-((1-甲基-4-哌啶基)氧基)苯基)氨基)-7-甲基-8H-嘌呤-8-酮;;AZ 3146;AZ-3146; 9-cyclopentyl-7,9-dihydro-2-((2-methoxy-4-((1-methyl-4-piperidinyl)oxy)phenyl)amino)-7-methyl-8h-purin-8-one;9-cyclopentyl-2-[2-methoxy-4-(1-methylpiperidin-4-yl)oxyanilino]-7-methylpurin-8-one |
