KU-55933 (ATM Kinase Inhibitor)

属性

沸点	628.01° C at 760 mmHg
熔点	229.98° C
折光率	1.71
溶解性	DMSO 33 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C
密度	1.4200

描述

应用	A cell-permeable, potent, selective and ATP-competitive ATM inhibitor
产品介绍	KU-55933是ATM抑制剂，IC50和Ki分别为13和2.2 nM，对DNA-PK，PI3K/PI4K，ATR和mTOR的活性较低。
生化机理	KU-55933 is a very potent, specific inhibitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase (IC50 = 13 nM). KU-22933 treatment sensitizes cancer cells to ionizing radiation and cytotoxic drugs. The compound KU-22933 blocks ATM-mediated phosphorylyation of p53, gH2AX, NBS1, and SMC1.
别名	KU 55933; KU55933；2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮;KU 55933;KU55933；2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one