VE-821

属性

溶解性	DMSO 74 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件	储存温度-20°C

描述

产品介绍	VE-821是ATP竞争性，高活性ATR选择性抑制剂，Ki和IC50分别为13 nM和26 nM，与ATM，DNA-PK和mTOR等的交叉反应极低。
生化机理	VE-821 is a novel ATR inhibitor. VE-821, sensitises tumour cells to DNA damage induced by radiation or chemotoxic drugs, by disrupting the DNA damage checkpoint and inhibiting DNA repair.
别名	VE821;VE 821; 3-氨基-6-[4-(甲基磺酰基)苯基]-N-苯基-2-吡嗪甲酰胺;VE821;VE 821;3-Amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide ; 3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide