Raltitrexed

属性

溶解性	Soluble in water (<1 mg/ml at 25 °C), DMSO (92 mg/ml at 25 °C), methanol (warmed), and ethanol (<1 mg/ml at 25 °C).
存贮条件	储存温度-20°C

描述

应用	An inhibitor of thymidylate synthase and DHFR.
产品介绍	Raltitrexed是一种胸苷酸合成酶抑制剂，抑制L1210细胞生长，IC50为9 nM。
备注	Raltitrexed is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
生化机理	Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. Raltitrexed is an inhibitor of DHFR.
别名	雷替曲塞;Tomudex; TDX; ZD1694; D1694; ICI-D1694;(S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid