NU7026

属性

溶解性	Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water
存贮条件	储存温度 2-8°C

描述

应用	An antiproliferative agent, and inhibitor of DNA-PK.
产品介绍	NU7026是一种有效的DNA-PK抑制剂，IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，抑制ATM和ATR活性。
备注	NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.
生化机理	DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.
别名	NU 7026; 2-(4-吗啉基)-4H-萘并[1,2-b]吡喃-4-酮;LY293646; NU-7026; LY 293646; LY-293646;LY293646; NU-7026; LY 293646; LY-293646; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one;DNA-PK Inhibitor II