| 货号 | CAS号 |
|---|---|
| A125440-50mg | 249921-19-5 |
| A125440-5mg | 249921-19-5 |
| A125440-10mg | 249921-19-5 |
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Anamorelin(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia. |
| 生化机理 |
Anamorelin hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite. |
| 别名 | RC-1291;ONO-7643;RC1291;ONO7643;RC 1291;ONO 7643；阿拉莫林; (3R)-1-(2-甲基丙氨酰-D-色氨酰)-3-苯甲基-3-哌啶 1,2,2-三甲基甲酰肼;RC-1291;ONO-7643;RC1291;ONO7643;RC 1291;ONO 7643;(3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide |
