LY2784544

属性

溶解性	DMSO 94 mg/mL (200.02 mM); Water <1 mg/mL (<1 mM); Ethanol 9 mg/mL (19.15 mM)
存贮条件	储存温度-20°C

描述

应用	A selective inhibitor of JAK2 mutant V617F.
产品介绍	LY2784544是一种有效的JAK2抑制剂，IC50为3 nM，作用于JAK2V617F有效，比作用于JAK1和JAK3选择性高8和20倍。Phase 2。
备注	LY2784544 is a potent JAK2 inhibitor with IC50 of 3 nM, effective in JAK2V617F, 8- and 20-fold selective versus JAK1 and JAK3. Phase 2.
生化机理	LY2784544 is identified as being highly selective inhibitor of JAK2 mutant V617F and has advanced into human clinical trials for the treatment of several myeloproliferative disorders.
别名	3-[(4-氯-2-氟苯基)甲基]-2-甲基-N-(5-甲基-1H-吡唑-3-基)-8-(4-吗啉甲基)咪唑并[1,2-b]哒嗪-6-胺;LY 2784544; LY-2784544;3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine;