| 产品介绍 |
KPT-185是一种选择性的CRM1抑制剂。 |
| 备注 |
KPT-185 is a selective CRM1 inhibitor. |
| 生化机理 |
KPT 185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferatve properties at submicromolar concentrations (IC50 values:100-500nM), induced apoptosis (average5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts. |
| 别名 |
(2Z)-3-[3-[3-甲氧基-5-(三氟甲基)苯基]-1H-1,2,4-三唑-1-基]-2-丙烯酸异丙酯;KPT185;KPT185; KPT 185;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester |
