| 应用 |
A P2X3 and P2X2/3 receptor antagonist |
| 产品介绍 |
A-317491是非核苷酸类P2X3和P2X2/3受体拮抗剂，能抑制由其介导的钙流。 |
| 生化机理 |
A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management. |
| 别名 |
A 317491;A317491;A 317491;A317491; 5-[[(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid |
