盐酸氨溴索
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离子通道

盐酸氨溴索

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上海阿拉丁生化科技股份有限公司
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产品特点
规格信息
货号 CAS号
A129556-100g 23828-92-4,18683-91-5
A129556-25g 23828-92-4,18683-91-5
A129556-5g 23828-92-4,18683-91-5
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产品描述

属性

熔点 235°C(dec.)(lit.)
溶解性 Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether.

描述

应用 An expectorant antioxidant and antiinflammatory agent
产品介绍 Ambroxol HCl是有效的神经性钠离子通道抑制剂,抑制抗TTX的钠离子电流,相位性阻滞,IC50为22.5 μM,抑制对TTX敏感的钠离子电流,IC50为100 μM。Phase 3。
备注 AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
生化机理 Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein.
别名 氨溴索 盐酸盐;2-氨基-3,5-二溴-N-(反式-4-羟基环己基)苄胺;Ambroxol Hydrochloride;trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride;2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine
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