| 应用 |
A potent inhibitor of MEK1 and MEK2. |
| 产品介绍 |
Pimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. |
| 备注 |
AS-703026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. Phase 1/2. |
| 生化机理 |
AS703026 is a highly selective and potent noncompetitive inhibitor of MEK1 and MEK2 (IC50 = 5-11 nM). |
| 别名 |
MSC1936369B;AS703026;N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺;MSC1936369B;AS-703026;AS 703026;N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide |
