| 应用 |
An antineoplastic selective MEK inhibitor |
| 产品介绍 |
AZD8330(ARRY-424704; ARRY-704)是非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。 |
| 备注 |
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. |
| 生化机理 |
AZD8330 potently and strongly inhibits MEK 1/2. AZD8330 has no inhibitory activity against over 200 other kinases including at concentrations up to 10 μM. AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK 1/2 inhibitor sensitive cell lines. |
| 别名 |
ARRY-424704; ARRY424704;ARRY704; AZD8330;2-(2-fluoro-4-iodophenylamino)-n-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide; AZD-8330; ARRY-704;2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺; |
