Ferrostatin-1 (Fer-1)

属性

溶解性	DMSO 52 mg/mL Water <1 mg/mL Ethanol 52 mg/mL
存贮条件	储存温度2-8℃

描述

应用	A potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis
产品介绍	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
备注	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
生化机理	Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
别名	;3-Amino-4-cyclohexylaminobenzoic Acid Ethyl Ester;