| 产品介绍 |
U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂，Ki值分别为45.1nM和4.5nM。 |
| 备注 |
U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II. |
| 生化机理 |
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX. |
| 别名 |
NSC 213841;U 104;4-[[[(4-氟苯基)氨基]羰基]氨基]苯磺酰胺;NSC-213841;MST-104;4-[[[(4-Fluorophenyl)amino]carbonyl]amino]benzenesulfonamide |
