| 货号 | CAS号 |
|---|---|
| P125726-10mg | 146464-95-1 |
| P125726-50mg | 146464-95-1 |
| 溶解性 | Soluble in DMSO (28 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). Insoluble in chloroform. |
| 存贮条件 | 储存温度-20°C |
| 应用 | An inhibitor of DHFR (dihydrofolate reductase) |
| 产品介绍 | Pralatrexate 是一种抗叶酸药，结构与叶酸类似，作用于一些细胞系，IC50低于300 nM。 |
| 备注 | Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
| 生化机理 | Pralatrexate acts an inhibitor of DHFR (dihydrofolate reductase). |
| 别名 | 10-炔丙基-10-去氮杂氨基蝶呤; N-(4-(1-((2,4-二氨基-6-蝶啶)甲基)-3-丁炔基)苯甲酰基)-L-谷氨酸;Folotyn;10-propargyl-10-deazaaminopterin;N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid |
