| 应用 |
An HIV-1 integrase inhibitor |
| 产品介绍 |
Elvitegravir (GS-9137, JTK-303)是人免疫缺陷病毒整合酶抑制剂，作用于HIV-1 IIIB， HIV-2 EHO和HIV-2 ROD时，IC50分别为0.7，2.8和1.4 nM。 |
| 备注 |
Elvitegravir (EVG, JTK-303/GS-9137) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively. |
| 生化机理 |
Elvitegravir is an inhibitor of HIV-1 integrase which is responsible for the strand-transfer step of integration. Studies indicate that Elvitegravir is effective against HIV-1 strains that are resistant to other agents such as nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), as a result of Elvitegravir's ability to block the function of HIV1 integrase. |
| 别名 |
埃替拉韦;GS-9137; JTK-303; EVG; D06677;6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
