| 应用 |
A potent immunosuppressive agent |
| 产品介绍 |
Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物，具有很强的免疫抑制剂。 |
| 生化机理 |
When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin . Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition |
| 别名 |
长川霉素;Immunomycin;FK 520;FR 900520;FR-900520;FR900520;FK-520;FK520 |
