| 应用 |
A selective SLC6A2 inhibitor. |
| 产品介绍 |
Atomoxetine HCl是一种选择性的去甲肾上腺素(NE)转运体抑制剂，Ki为5 nM，作用于人体5-HT和DA转运体亲和力比其低15和290倍。 |
| 备注 |
Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.Phase 4. |
| 生化机理 |
Tomoxetine hydrochloride (Atomoxetine, LY 139603) is a competitive and specific inhibitor of SLC6A2 while demonstrating weak ST and DAT inhibition as studied in synaptosomes of rat hypothalamus. Additionally, studies indicate that this (-) optical isomer is more effective than the (+) isomer, LY139602 (ent S-(+)-Atomoxetine Hydrochloride;). In the prefrontal cortex of rats, Tomoxetine was reported to not cause an increase in dopamine within the striatum or nucleus accumbens which may be useful in additional research studies investigating the reward pathways of the brain. Tomoxetine hydrochloride is an inhibitor of NMDA. |
| 别名 |
盐酸托莫西汀;盐酸阿托莫西汀; (R)-N-甲基-3-(2-甲基苯氧基)-3-苯丙基胺盐酸盐;(R)-Tomoxetine Hydrochloride;(R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine Hydrochloride; LY 139603 |
