Ketoprofen

属性

熔点	92-97°
敏感性	对光敏感
溶解性	Soluble in ethanol (51 mg/ml at 25 °C), DMSO (51 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), DMF (≥20 mg/ml), and PBS (pH 7.2) (≥0.5 mg/ml).
存贮条件	储存温度2-8℃

描述

应用	An inhibitor of Cox-1 and Cox-2.
产品介绍	Ketoprofen 是一种非选择性的NSAID，作用于人重组COX-1和COX-2， IC50分别为0.5 μM和2.33 μM。
备注	Ketoprofen (Actron) is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
生化机理	Ketoprofen is a non-selective NSAID which inhibits both human recombinant Cox-1 (IC50 of 0.5 μM) and Cox-2 (IC50 of 2.33 μM). Ketoprofen is used for its antipyretic, analgesic, and anti-inflammatory properties by inhibiting Cox-1 and Cox-2 (cyclooxygenase-1 and -2) enzymes reversibly, which decreases production of pro-inflammatory prostaglandin precursors.
别名	2-(3-苯甲酰苯基)丙酸;酮基布洛芬;α-甲基-3-苯甲酰基苯乙酸;酮洛芬;2-(3-Benzoylphenyl)propionic acid

标识符号	GHS06
信号词	Danger
危害声明	H301-H315-H319-H335
警示性声明	P261-P301 + P310-P305 + P351 + P338
个人防护设备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS	UE7570000
WGK德国	3