| 应用 |
A selective receptor agonist for the δ-opioid receptor |
| 产品介绍 |
ADL5859是δ-阿片受体选择性激动剂，Ki为0.8 nM，对hERG有弱抑制性。 |
| 备注 |
ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Phase 2. |
| 生化机理 |
ADL-5859 (ADL5859) is an δ-opioid receptor agonist (Ki=0.84 nM, EC50=20 nM). ADL-5859 (ADL5859) is an agonist agent that selectively stimulates the δ-opioid receptor with potential application in a wide range of inflammatory, neuropathic and acute pain conditions. In addition, Delta agonists are thought to modulate other biological processes that may manifest themselves in disease states or conditions such as overactive bladder and depression.ADL-5859 (ADL5859) is useful for inflammatory, neuropathic and acute pain conditions. |
| 别名 |
ADL5859; ADL 5859; N,N-二乙基-4-(5-羟基螺(2H-1-苯并吡喃-2,4'-哌啶)-4-基)苯甲酰胺盐酸盐;;ADL5859; ADL 5859;N,N-Diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)benzamide hydrochloride; |
