| 产品介绍 |
Naproxen Sodium 是一种非选择性环氧合酶(COX)抑制剂，作用于COX-1和COX-2时，IC50分别为8.7 μM和5.2 μM。 |
| 备注 |
Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
| 生化机理 |
Naproxen is an approximately equipotent inhibitor of Cox-1 (IC50 of 2.2 μg/mL) and Cox-2 (IC50 of 1.3 μg/mL) in intact cells. Naproxen decreases the in vitro LPS-induced PGE2 and TXB2 production in rats and humans with IC50 of 30.7 μM and 79.5 μM for PGE2 inhibition, 72.4 μM and 48.3 μM for TXB2 inhibition, respectively. Naproxen produces concentration-related inhibition of TXB2 production from human platelets and LPS-induced TXB2 production from human mononuclear cells with plC50 values (-log concentration inhibiting TXB2 by 50%) of 5.7 and 6.4, respectively, and exhibits slightly inhibitory selectivity for constitutive and induced Cox-2 (IC50 Cox-1/IC50 Cox-2 of 6.3). Only high concentration of Naproxen can significantly induce apoptosis at 48 hours in HCA-7 colon cancer cells (IC50 of 1.45 mM). |
| 别名 |
Naprelan; Anaprox; Naprosyn; Aleve;(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt;萘普生钠; S-(-)2-(6-甲氧基-2-萘基)丙酸钠;(S)-6-甲氧基-α-甲基-2-萘乙酸 钠盐 |
