| 应用 |
A selective P2Y66 receptor antagonist. |
| 产品介绍 |
MRS 2578是一种有效的P2Y6受体抑制剂，IC50为37 nM，对P2Y1， P2Y2， P2Y4和P2Y11受体的作用活性很弱。 |
| 备注 |
MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| 生化机理 |
MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66. |
| 别名 |
MRS-2578; MRS2578; N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲;MRS-2578; MRS2578; 1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane;N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea |
