| 应用 |
A selective and reversible inhibitor of IKKβ (IKK-2) |
| 产品介绍 |
SC-514是一种口服有效的，ATP竞争性的IKK-2抑制剂，IC50为3-12 μM，抑制NF-κB依赖性的基因表达，不抑制其他IKK异构体或其他丝-苏氨酸和酪氨酸激酶。 |
| 备注 |
SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. |
| 生化机理 |
SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. |
| 别名 |
GK 01140; SC 514; SC514; GK-01140; GK01140;4-氨基-[2,3']联噻吩-5-甲酰胺;GK 01140;SC 514;SC514;GK-01140;GK01140;4-Amino-[2,3']bithiophenyl-5-carboxamide |
