| 应用 |
A nucleoside analog structurally related to Acyclovir. |
| 产品介绍 |
Ganciclovir 是一种抗病毒药，作用于猫科动物1型疱疹病毒，IC50为5.2 μM。 |
| 备注 |
Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. |
| 生化机理 |
Ganciclovir is a nucleoside analog structurally related to Acyclovir that acts as a prodrug activated by phosphorylation. Ganciclovir has been used in the study of “suicide” gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents. |
| 别名 |
更昔洛韦;9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤;BW 759; 2'-Nor-2'-deoxyguanosine;2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2'-NDG; |
