| 货号 | CAS号 |
|---|---|
| G127198-25g | 10238-21-8 |
| G127198-5g | 10238-21-8 |
| G127198-100g | 10238-21-8 |
| 熔点 | 171-174°C |
| 折光率 | 1.62 |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water. |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1****** |
| 应用 | An ATP-dependent KIR6 and CFTR Cl- channel blocker |
| 产品介绍 | Glibenclamide (格列本脲; Glyburide) 是磺酰脲类化合物，能调节胰岛素的产生。 |
| 备注 | Glyburide (Diabeta) is an anti-diabetic compound in a class of medications known as sulfonylureas, closely related to sulfa agents. |
| 生化机理 |
Glibenclamide is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glibenclamide, a sulphonylurea oral hypoglycaemic agent is a widely used antagonist of cromakalim-activated K+ channels in smooth muscle. Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. Glibenclamide is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines. |
| 别名 | 格列本脲;优降糖; 5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺; N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N′-环己基脲; 5-氯-N-[4-(3-环己基脲基磺酰基)苯基乙基]-2-甲氧基苯甲酰胺;Glyburide;5-Chloro-N-[4-(3-cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide;N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea |
