| 应用 |
A competitive indoleamine 2,3-dioxygenase inhibitor |
| 产品介绍 |
IDO5L是高活性IDO1抑制剂，IC50为67 nM。 |
| 生化机理 |
In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM. In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells. |
| 别名 |
IDO5L;4-氨基-N-(3-氯-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒;;IDO5L;indoleamine-2,3-dioxygenase inhibitor；4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide |
